Bactericidal activity study of ZrO2-Ag2O nanoparticles
In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO2-Ag2Onanoparticles by sol-gel method. The nanoparticles were anal...
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| Other Authors: | , , , |
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| Format: | Artículo |
| Language: | en_US |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://doi.org/10.1177/1559325820941374 https://journals.sagepub.com/doi/full/10.1177/1559325820941374 |
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| Summary: | In view of the continuous resistance to antibacterial agents by bacteria and the existing problems of silver nanoparticles as an
antibacterial agent, this study reports on the synthesis of pure zirconium oxide, silver oxide, and ZrO2-Ag2Onanoparticles by sol-gel
method. The nanoparticles were analyzed and tested for their antibacterial activity against gram-positive bacteria of Bacillus subtilis,
Streptococcus mutans, Staphylococcus aureus, and gram-negative of Escherichia coli, Pseudomonas aeruginosa, and Klebsiella oxytoca. X-ray
diffraction showed the monoclinic ZrO2, cubicAg2O, and peaks corresponding to ZrO2 and Ag2O in their mixed samples. Scanning
electron microscopy showed spherically shaped nanoparticles while dynamic light scattering analysis showed ZrO2 (76 nm), Ag2O
(50 nm), and ZrO2-Ag2O samples between 14 and 42 nm. The Fourier Transformed Infrared spectroscopy spectra of ZrO2 gave
bands at 480 cm 1 to 750 cm 1 (M-O stretching) with Ag2O at 580 cm 1, while ZrO2-Ag2O samples showed bands at 760 cm 1.
The screening by agar diffusion assay revealed a pronounced increase in the antibacterial activity of ZrO2-Ag2O against all the tested
bacteria when compared with the pure ZrO2 and Ag2O. The improved antibacterial activity of ZrO2-Ag2O largely results from the
chemical stability conferred on it by the ZrO2 as observed from the zeta potential measurement. |
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