The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity
DapE is a Zn2+-metallohydrolase recognized as a drug target for bacterial control. It is a homodimer that requires the exchange of interface strands by an induced fit essential for catalysis. Identifying novel anti-DapE agents requires greater structural details. Most of the characterized DapEs are...
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| 格式: | Artículo |
| 语言: | en_US |
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2024
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| 在线阅读: | https://doi.org/10.1016/j.ijbiomac.2024.132281 https://www.sciencedirect.com/science/article/abs/pii/S0141813024030861?via%3Dihub |
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